A third-minute screamer from Jordan Nobbs and a deflected Rachel Yankey free-kick in the 57th minute was enough to wrap up a 2-0 victory for Arsenal.
The visitors were given a chance to get back into the game when Emma Mitchell was dismissed for a professional foul in the Gunners area on Kirsty Linnett, however Cherie Rowlands saved the resulting spot-kick from Izzy Christiansen.
Blues Ladies: Spencer, Weston, Harrop, Bassett, Christiansen, Linnett, Carney (Simpkins 70), Potter, Moore, Lawley, Westwood (Mannion 60). Subs not used: Earps, Torkildsen, George, Wilkinson, Haines.
Blues Ladies: Spencer (Earps 63); Weston, Mannion, Westwood, Harrop; Moore, Potter, Christianssen; Haines (Wilkinson 46), Linnett, Lawley. Subs not used: Simpkins, Tokildsen, Bassett, Williams, George.