The Professional Development League Two fixture is being played at Crewe's Alexandra Stadium.
Blues Development Squad coach Richard Beale has named a squad with some experience.
Amongst the travelling party are Viv Solomon-Otabor, Mitch Hancox, Koby Arthur and recent Kidderminster Harriers midfield recruit Luke Maxwell.
When the two sides met in the corresponding fixture at Blues in December, Beale's side won 1-0 thanks to a goal from Wes McDonald.
Blues Under-21s from
: Trueman, Weaver, Harding, Hancox, Mbende, Martin, Bernard, Baba, Cooper, Arthur, Solomon-Otabor, Jones, O'Neill, McDonald, McFarlane, Maxwell.