Che Adams played 45 minutes to boost his fitness and Carl Jenkinson returned to action for just over an hour.BCFC
Kyle McFarlane, following up his own penalty that was saved, got the equaliser in the 67th minute as Blues laid siege in and around the visitors' area.
Blues had fallen behind in the 29th minute when Connor Kirby met a right wing cross to just about squeeze his header past Jake Weaver inside the post.
And after the break Blues ramped things up significantly and the Owls defended resiliently to withstanding constant pressure.
There were significant selections in the Blues side, with Che Adams gaining 45 minutes to boost his fitness and Carl Jenkinson returning to action for just over an hour.
Wes Harding, who has been sidelined for four months, was back to captain the team at right-back and Odin Bailey also got a half under his belt after his spell on the sidelines.
Adams might have got his name on the scoresheet when the goalkeeper spilled a cross on the run to the byline from Jenkinson but his backheel attempt as he readjusted was blocked in front of goal.
Blues made most of the running in the opening period but were jolted when Kirby opened the scoring.
Nevertheless they continued to plug away and as the half neared its close could have levelled. Charlie Lakin showed quick feet to create space and lay a forward pass towards Adams and after Dan Wallis made a hash of clearing the bouncing ball, Adams turned back on himself to swivel a shot just wide from 18 yards.
And McFarlane - back from his loan to Nuneaton Town - stuck a good chance over the crossbar, coming in from the left to thump Adams' knock down from Steve Seddon's deep cross first time towards the target.
At the interval Blues withdrew Adams and Bailey and readjusted their line-up. McFarlane went up front to lead the line and Olly McCoy came on to play wide on the left. Dominic Bernard moved forward into midfield from centre-half - Luke Maxwell entering the fray - and Jenkinson played inside, as one of the two in central midfield ahead of the deeper-lying Lakin.
Blues really took it to Sheffield in the second period with O'Keefe particularly performing strongly along with dangerous deliveries from McCoy in particular.
They squared the match up when O'Keefe was felled during a driving run on the right-hand side of the area.
McFarlane's penalty struck the legs of Wallis in the Owls' goal, but the ball rebounded back towards him to sidefoot in.
Wallis made a stunning save to deny O'Keeffe, who dived in bravely to head a shot by McFarlane that bounced into the turf despite the close attentions of a defender's swinging boot.
And there were other openings for Blues, with McCoy seeing a shot blocked and go wide after being set by O'Keeffe's touch back.
That was typical of Sheffield's dogged defending, they were put under the cosh continually in the second-half and were forced to sit in. But Blues couldn't quite make their possession and pressure pay.
Blues: Weaver, Harding, Seddon, Bernard, Martin, Lakin, Jenkinson (McDonald 61), O'Keeffe, Adams (McCoy ht), Bailey (Maxwell ht), McFarlane. Not used: Siviter, Hutton.