The game against the Seagulls marks the first of three Group E fixtures, thereafter Blues play host to West Ham United in November and make the trip to the London City Lionesses in December.
Blues will be buoyed from the weekend - picking up a deserved point on their travels against a good West Ham side - a team they also face in this competition.
The match will be streamed live on Blues Women's Facebook page.
And there will be a familiar face on commentary, as BluesTV's Hayden Atkins is joined by Christie Murray.
Coverage begins at approximately 7.15pm ahead of the 7.30pm kick-off on Wednesday 13 October.
See you over on the stream!